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Ionis Pharmaceuticals Inc (IONS) — chart, structure and Closelooknet read

The Closelooknet read

Ionis Pharmaceuticals develops RNA-targeted medicines, treatments that alter how specific messenger RNA produces or suppresses proteins, mainly for rare and metabolic diseases. Its marketed products include SPINRAZA for spinal muscular atrophy, WAINUA for hereditary transthyretin amyloidosis, TRYNGOLZA for familial chylomicronemia syndrome, and several others such as DAWNZERA, QALSODY, TEGSEDI and WAYLIVRA.

Detail below: the desk's view, the earnings record, peers and the company snapshot; daily prices on the price-history tab. Research diary readings, not advice.

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Signals for this name

Every Closelooknet reading that exists for IONS, from the same nightly bakes the boards use. Research diary readings, not advice.

Weather around the name 3 macro readings: Money Temperature, Factor regime, Sovereign pressure

The weather around this name

Macro readings that apply by membership — the regime, the factor tape, the sector cell, the funding backdrop.

  • Money Temperature Composite 47/100 · S&P 500 fund at 48, above its 200-day averageEight instruments scored on position, momentum, volume, volatility and fragility — the regime every name trades inside. Temperature lab → 2026-11-06
  • Factor regime Defensive rotation — low-vol leading, regime-change watchMomentum against low volatility (SPMO / SPLV): below its 50-day trend, 60th percentile of the window, -22.8% over 20 sessions. Factor regime → 2026-11-06
  • Sovereign pressure Index -2.05 · down 2.95 over 21 sessionsG7 long-end yields, 10s30s and the slope — the funding weather for every balance sheet on this site. Sovereign pressure → 2026-11-05
How it trades on rate days beta 0.44 to TLT · on the worst bond days it fell more than the market

How it trades on rate days

How IONS has moved when long-dated Treasury yields rise — measured against TLT, the 20+ year Treasury fund.

  • Beta to long bonds, 1 year 0.44 — shows only a loose link to bond moves for every 1% move in TLT (20+ year Treasuries), Ionis Pharmaceuticals Inc moved 0.44% on average · correlation 0.10 · higher than 35% of US names
  • Beta, last 3 months 0.66 more rate-sensitive lately than over the year
  • On the 10 worst bond days −1.18% on average against −0.74% for the S&P 500 the 10 sessions of the past year in which TLT fell most, i.e. long yields rose most
  • Latest of those days −0.27% TLT −1.29% that day 2026-09-24

Daily total returns from the adjusted price series; a TLT down day is a day long yields rose. Beta = the average move of the name for a 1% move in TLT. Past sensitivity, not a forecast. An investment diary, not a recommendation.

Who it is priced against Biotechnology · United States · 8 names with week and year-to-date

Peer group

Biotechnology · United States

This name carries no Closelooknet score, so its cohort ranks on trend state — distance to the 50- and 200-day averages — never on a score it does not have.

Compared against IONS on the nightly bakes; the Peers tab ranks the cohort on the Closelooknet scores where it exists.

Company snapshot — Ionis Pharmaceuticals Inc

IONS in five paragraphs: what it makes and sells, where it sits in the Closelooknet stack, who it is priced against, why we track it, what we watch. Research diary, not advice.

What it does
Ionis Pharmaceuticals develops RNA-targeted medicines, treatments that alter how specific messenger RNA produces or suppresses proteins, mainly for rare and metabolic diseases. Its marketed products include SPINRAZA for spinal muscular atrophy, WAINUA for hereditary transthyretin amyloidosis, TRYNGOLZA for familial chylomicronemia syndrome, and several others such as DAWNZERA, QALSODY, TEGSEDI and WAYLIVRA. The pipeline carries multiple Phase 3 candidates, including olezarsen, eplontersen, pelacarsen, bepirovirsen and ulefnersen, and the company works with Biogen on neurological disorders. It is based in Carlsbad, California.
Where it sits in the stack
Ionis sits outside Closelooknet's AI build-out stack; within our universe it belongs to the healthcare and biotechnology sleeve, built on RNA-targeted drug development rather than hardware or data infrastructure.
Who it is priced against
Closelooknet's peer group carries no formal comparison set for Ionis; the competitor the market often names alongside it is Alnylam Pharmaceuticals, another RNA-medicine developer.
Why Closelooknet tracks it
Ionis is a Russell 1000 constituent; it does not yet carry a Closelooknet score, and the diary has not quoted it in an edition.
What the diary watches
The diary watches whether upcoming Phase 3 readouts, particularly for olezarsen, change the stock's extended downward chart pattern before analysts revise their framing.

Ionis Pharmaceuticals Inc (IONS) trades on US exchanges.

Written from the company’s public profile and Closelooknet’s own readings, 2026-09-17. Descriptive, refreshed with the registry; corrections welcome via the imprint. closelook.net is an investment research diary — market structure, index membership and scores are our own readings, not investment advice. Related: index compare · sector dispersion · scanner.

The Street on this name 7 analyst actions on the wire · latest: upgrade by BMO Capital, 2026-10-21

The Street on this name

Analyst actions and the latest print for IONS from the Closelooknet wires — third-party opinions on the record, not our readings.

  • Upgrade BMO Capital — Market Perform → Outperform Upgraded to Outperform from Market Perform 2026-10-21
  • Price target Raymond James — target 79 from 84 Target cut to $79 from $84 (+76.8% to spot) 2026-10-20
  • Price target Guggenheim — target 80 Target set to $80 (+55.5% to spot) 2026-09-15

7 actions on the analyst wire since 2026-08-13: 1 upgrade, 1 initiation, 5 target changes. Analyst wire → · Earnings wire →

FAQ · from the current data · as of 2026-11-07

Quick answers

What is Ionis Pharmaceuticals Inc (IONS)?

Ionis Pharmaceuticals Inc trades as IONS on the US exchange (United States) in the Closelooknet research universe, as of the registry build of 2026-11-07.

Is IONS in a Closelooknet index?

Not currently — Ionis Pharmaceuticals Inc is tracked in the Closelooknet research universe but is not a constituent of a Closelooknet functional index as of 2026-11-07.

Where does IONS trade against its moving averages?

Ionis Pharmaceuticals Inc trades 15.8% below its 50-day and 40.1% below its 200-day moving average (8.0% below its 20-day). As of 2026-11-06 — a technical state from the nightly Closelooknet bake, not advice. The Technical tab carries the full row.

How does Ionis Pharmaceuticals Inc compare with its peers?

Against its peer group (Biotechnology · United States), Ionis Pharmaceuticals Inc (IONS) sits 54.6% below its 52-week high, 15.8% below its 50-day average; Moderna Inc (MRNA) is 5.0% below, Exelixis Inc (EXEL) is 5.6% below, Ginkgo Bioworks Holdings (DNA) is 38.0% below, as of 2026-11-06. Put any of them next to IONS in the chart grid (2×1 or 2×2) and the page lays the companies side by side: performance, trend, valuation, margins and our money-flow reading.

How does Ionis Pharmaceuticals Inc trade when bond yields rise?

Over the past year Ionis Pharmaceuticals Inc had a beta of 0.44 to TLT, the long-dated Treasury fund — it shows only a loose link to bond moves, higher than 35% of US names. On the 10 sessions in which long bonds fell most it moved −1.18% on average, against −0.74% for the S&P 500. As of 2026-11-06; The "How it trades on rate days" block on this page carries the lines.

What does Ionis Pharmaceuticals Inc do?

Ionis Pharmaceuticals develops RNA-targeted medicines, treatments that alter how specific messenger RNA produces or suppresses proteins, mainly for rare and metabolic diseases. Its marketed products include SPINRAZA for spinal muscular atrophy, WAINUA for hereditary transthyretin amyloidosis, TRYNGOLZA for familial chylomicronemia syndrome, and several others such as DAWNZERA, QALSODY, TEGSEDI and WAYLIVRA. The pipeline carries multiple Phase 3 candidates, including olezarsen, eplontersen, pelacarsen, bepirovirsen and ulefnersen, and the company works with Biogen on neurological disorders. Closelooknet's peer group carries no formal comparison set for Ionis; the competitor the market often names alongside it is Alnylam Pharmaceuticals, another RNA-medicine developer. (Company snapshot of 2026-09-17.)

Where does Ionis Pharmaceuticals Inc sit in the AI build-out?

Ionis sits outside Closelooknet's AI build-out stack; within our universe it belongs to the healthcare and biotechnology sleeve, built on RNA-targeted drug development rather than hardware or data infrastructure. Ionis is a Russell 1000 constituent; it does not yet carry a Closelooknet score, and the diary has not quoted it in an edition. (Company snapshot of 2026-09-17.)

What has Wall Street done on Ionis Pharmaceuticals Inc recently?

The most recent analyst action on Ionis Pharmaceuticals Inc on the Closelooknet wire is a upgrade by BMO Capital on 2026-10-21 (Market Perform → Outperform). 7 actions on the analyst wire since 2026-08-13: 1 upgrade, 1 initiation, 5 target changes. Analyst actions are third-party opinions recorded by the wire, not Closelooknet readings. The “The Street on this name” block on this page lists the moves; the full feeds are the analyst wire and the earnings wire.

What does this page show?

A live price chart with SMA overlays and drawing tools for IONS, performance metrics, index-membership context and the Closelooknet structure read — an investment research diary view, not investment advice.

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Related in the Closelooknet universe

then Biotechnology. Scored names rank on their Closelooknet score; names without one rank on trend state — above or below their 50- and 200-day averages — never on a score they do not carry.